"Mutator®" is a computational tool from the University of Split for predicting how single or double amino acid substitutions could improve the therapeutic index (TI)* of helical antimicrobial peptides (AMPs).

At the moment, the underlying algorithm has been trained on a test set helical AMPs of anuran origin [1]. It has been tested and confirmed to work on anuran AMPs [2-5].

The predicted therapeutic index (TI)* is based on the HC50 and MIC against E. coli.

Please paste your sequence. The input for the prediction program is one-letter amino acid code for peptide primary structure without free spaces or numbers. The output is given as suggested sequences and associated numbers: TI(D-descriptor).

Please cite the reference: Nédia Kamech†, Damir Vukičević‡, Ali Ladram†, Christophe Piesse §, Julie Vasseur†, Viktor Bojovi懇 , Juraj Simunić‡ and Davor Juretić‡: "Improving the selectivity of antimicrobial peptides from anuran skin". Journal of Chemical Information and Modeling, 52, 3341–3351 (2012)
† Université Pierre et Marie Curie - Paris 06, Equipe Biogenè des signaux peptidiques, ER3, 7 Quai Saint-Bernard, 75252 Paris cedex 05, France
‡ Faculty of Science, University of Split, 21000 Split, Croatia
§ Université Pierre et Marie Curie - Paris 06, Ingéerie des protées, Institut de Biologie intéative IFR 83, 7 Quai Saint-Bernard, 75252 Paris cedex 05, France
‡‡Ruđer Bošković Institute, Centre for Informatics and Computing, 10000 Zagreb, Croatia